buy nembutal online delivery Intramuscular Administration
IM injection of the sodium salts of barbiturates goes deep into a large muscle, and a volume of 5 mL cannot surpass at any one site because of possible tissue irritation. After IM injection of a hypnotic dose, the patient’s vital signs will undergo monitoring. The usual adult dosage of NEMBUTAL Sodium Solution is 150 to 200 mg as a single IM injection; the recommended pediatric dosage ranges from 2 to 6 mg/kg as a single IM injection not to exceed 100 mg.
NEMBUTAL Sodium Solution will go in a mix with any other medication or solution. IV injection is not for conditions in which other routes are not feasible, either because the patient is unconscious (as in cerebral hemorrhage, eclampsia, or status epilepticus), or because the patient resists (as in delirium), or because prompt action is imperative. Slow IV injection is essential, and patients should be carefully observed during administration. This requires that blood pressure, respiration, and cardiac function be maintained, vital signs be recorded, and equipment for resuscitation and artificial ventilation be available. The rate of IV injection should not exceed 50 mg/min for pentobarbital sodium.
There is no average intravenous dose of NEMBUTAL Sodium Solution (pentobarbital sodium injection) that can rely on to produce similar effects in different patients. The possibility of overdose and respiratory depression is remote when the drug is injection goes slowly in fractional doses.
A commonly used initial dose for the 70 kg adult is 100 mg. Proportional reduction in dosage is for pediatric or debilitated patients. At least one minute is necessary to determine the full effect of intravenous pentobarbital. If necessary, additional small increments of the drug is give up to a total of from 200 to 500 mg for normal adults.
In convulsive states, dosage of NEMBUTAL Sodium Solution will go to a minimum. To avoid compounding the depression which may follow convulsions. The injection can go slowly with due regard to the time. Required for the drug to penetrate the blood-brain barrier.
Special Patient Population
Dosage will be less in the elderly or debilitated because these patients may be more sensitive to barbiturates. Dosage will also be little for patients with impaired renal function or hepatic disease.
Parenteral drug products must go for inspection visually for particulate matter and discoloration prior to administration, whenever solution containers permit. Also, solutions for injection showing evidence of precipitation will have use.