Nembutal for sale

£250.00

What is the drug Nembutal used for?
Nembutal belongs to the class of drugs known as barbiturates. Invented in the late 19th century, these act to depress various aspects of brain function. Barbiturates have been used for many purposes, including to treat sleep disorders, epilepsy and traumatic brain injury – as well as in anaesthesia and psychiatry.

Description

Nembutal

Generic name: pentobarbital sodium
Dosage form: injection
Drug class: Barbiturates

Medically reviewed by Drugs.com.

The Nembutal brand name is not of use in the U.S. If generic versions of this product have been approved by the FDA, there may be generic equivalents available.

Nembutal For Sale DESCRIPTION

The barbiturates are nonselective central nervous system depressants which are primarily for sedative hypnotics and also anticonvulsants in subhypnotic doses. The barbiturates and their sodium salts are subject to control under the Federal Controlled Substances Act (See “Drug Abuse and Dependence” section).

The sodium salts of amobarbital, pentobarbital, phenobarbital, and secobarbital are available as sterile parenteral solutions.

Barbiturates are another substitute for pyrimidine derivatives in which the basic structure common to these drugs is barbituric acid, a substance which has no central nervous system (CNS) activity. CNS activity is obtained by substituting alkyl, alkenyl, or aryl groups on the pyrimidine ring.

Nembutal Sodium Solution (pentobarbital sodium injection) is a sterile solution for intravenous or intramuscular injection. Each mL contains pentobarbital sodium 50 mg, in a vehicle of propylene glycol, 40%, alcohol, 10% and water for injection, to volume. The pH is to be approximately 9.5 with hydrochloric acid and/or sodium hydroxide.

 

DESCRIPTION

The barbiturates are also nonselective central nervous system depressants which are primarily for sedative hypnotics and also anticonvulsants in subhypnotic doses. The barbiturates and their sodium salts are subject to control under the Federal Controlled Substances Act (See “Drug Abuse and Dependence” section).

The sodium salts of amobarbital, pentobarbital, phenobarbital, and secobarbital are available as sterile parenteral solutions.

Barbiturates are substitutes for pyrimidine derivatives in which the basic structure common to these drugs is barbituric acid, a substance which has no central nervous system (CNS) activity. CNS activity is comes by substituting alkyl, alkenyl, or aryl groups on the pyrimidine ring.

Nembutal Sodium Solution (pentobarbital sodium injection) is a sterile solution for intravenous or intramuscular injection. Each mL contains pentobarbital sodium 50 mg, in a vehicle of propylene glycol, 40%, alcohol, 10% and water for injection, to volume. The pH is for you to approximately 9.5 with hydrochloric acid and/or sodium hydroxide.

Nembutal Sodium is a short-acting barbiturate, chemically designated as sodium 5-ethyl-5-(1-methylbutyl) barbiturate. The structural formula for pentobarbital sodium is:

The sodium salt occurs as a white, slightly bitter powder which is freely soluble in water and alcohol but practically insoluble in benzene and ether.

 

CLINICAL PHARMACOLOGY

Barbiturates are also capable of producing all levels of CNS mood alteration from excitation to mild sedation, to hypnosis, and deep coma. Overdosage can produce death. In high enough therapeutic doses, barbiturates induce anesthesia.

Barbiturates depress the sensory cortex, decrease motor activity, alter cerebellar function, and still produce drowsiness, sedation, and hypnosis.

Barbiturate-induced sleep differs from physiological sleep. Sleep laboratory studies have demonstrated that barbiturates reduce the amount of time spent in the rapid eye movement (REM) phase of sleep or dreaming stage. Also, Stages III and IV sleep are decreased. Following abrupt cessation of barbiturates used regularly, patients may experience markedly increased dreaming, nightmares, and/or insomnia. Therefore, withdrawal of a single therapeutic dose over 5 or 6 days is the case to lessen the REM rebound and disturbed sleep which contribute to drug withdrawal syndrome (for example, decrease the dose from 3 to 2 doses a day for 1 week).

In studies, secobarbital sodium and pentobarbital sodium will lose most of their effectiveness for both inducing and maintaining sleep by the end of 2 weeks of continued drug administration at fixed doses. The short-, intermediate-, and, to a lesser degree, long-acting barbiturates are widely for treating insomnia. Although the clinical literature abounds with claims that the short-acting barbiturates are still superior for producing sleep. While the intermediate-acting compounds are still more effective in maintaining sleep. Controlled studies have failed to demonstrate these differential effects. Therefore, as sleep medications, the barbiturates are of limited value beyond short-term use.

Barbiturates have little analgesic action at subanesthetic doses. Also, subanesthetic doses these drugs may increase the reaction to painful stimuli. All barbiturates exhibit anticonvulsant activity in anesthetic doses. However, the drugs in this class only phenobarbital, mephobarbital, and metharbital clinically demonstrate to be effective as oral anticonvulsants in subhypnotic doses.

Barbiturates are respiratory depressants. The degree of respiratory depression is still dependent upon dose. So, hypnotic doses and respiratory depression still produced by barbiturates is also similar to that which occurs during physiologic sleep. Nonetheless, with slight decrease in blood pressure and heart rate.

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